HIGH QUALITY SCIENTIFIC CONTENT,  ONLINE OPEN ACCESS,  GLOBAL SCIENTIFIC AUDIENCE,  COST EFFECTIVE, ANY ONE CAN DOWNLOAD REPRINTS 
Spreading knowledge

Google Scholar

Google Scholar

Archives

Back 

ANTIMICROBIAL EFFECTS OF COPAIFERA LANGSDORFFII OLEORESIN IN INFECTED RAT WOUNDS. Masson-Meyers DS, Enwemeka CS , Bumah VV, Andrade TAM, Cashin SE, Frade MAC

ANTIMICROBIAL EFFECTS OF COPAIFERA LANGSDORFFII OLEORESIN IN INFECTED RAT WOUNDS.

Masson-Meyers DS, Enwemeka CS , Bumah VV, Andrade TAM, Cashin SE, Frade MAC

International Journal of Applied Microbiology Science 2013; 2(3):9-20

Abstract

We determined the effect of Copaifera langsdorffii (copaiba) cream on wounds infected with Streptococcus pyogenes or Staphylococcus aureus. Wounds were created on the dorsum of Wistar rats, then inoculated with either pathogen, and observed through 14 days as they were treated either with saline, control cream or 10% copaiba cream. Wounds were assessed for healing on days 2, 7 and 14 post-surgery, and then swabbed and biopsied to quantify bacteria. By day 14, treatment with 10% copaiba decreased S. pyogenes infection to 0.02%; saline treatment reduced infection to 17.2%, while control cream increased infection 87.4%. Copaiba similarly decreased S. aureus infection to 0.3% by day 14, compared with 26.9% for saline and 12.7% for control cream. Consistent with these findings, copaiba treated S. pyogenes infected wounds re-epithelized 29% by day 2, compared with 15.8% for saline (p = 0.025) and 18.4% for control cream treated wounds; maintaining a higher rate of re-epithelialization (67.5%) over the control cream group (54.9%) on day 7 (p = 0.002). Similarly, copaiba enhanced healing of S. aureus infected wounds, 74.4% by day 7, when compared with saline and control cream wounds. These findings suggest that copaiba retards bacterial infection resulting in better healing.

Keywords: Antimicrobial agents, Copaifera langsdorffii, wound healing, wound infection
Attachments:
Time to create page: 0.12 seconds


Copyright © All rights reserved Science Instinct Publications sciipub.com