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DEVELOPMENT AND EVALUATION OF ANTIMICROBIAL WOUND DRESSINGS IMPREGNATED WITH HERBAL NANOCAPSULES. Anna Joice P, R Parthasarathi

DEVELOPMENT AND EVALUATION OF ANTIMICROBIAL WOUND DRESSINGS IMPREGNATED WITH HERBAL NANOCAPSULES.

Anna Joice P, R Parthasarathi

International Journal of Applied Microbiology Science 2012; 1(3): 35-41

Abstract

The aim of the present study was to develop antimicrobial wound dressings impregnated with Azadirachta indica plant leaves as herbal nanocapsules and evaluate their antimicrobial activity against the wound pathogens in in-vitro. The nanocapsules were used to increase the durability of dressings by sustained release of compounds. The nanocapsule were formulated by cation induced controlled gelification method. The antimicrobial activity of wound dressing was studied by zone of inhibition and quantitative analysis by standard methods using Staphylococcus aureus, Proteus vulgaris, Bacillus cereus, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae. The physical characterization of nanoparticle was performed by Field Emission Scanning Electron Microscope and Dynamic Light Scattering analysis. The nanoparticles were found to be spherical in shape and approximately in the size range of 30-40 nm. The neem nanocapsule containing dressings recorded 100% bacterial reduction against all the test pathogens.

Keywords: Azadirachta indica, Nanocapsules, Wound dressings, Zeta Potential
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