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STUDY ON SYNTHESIS OF IMIDES AND ITS VARIOUS PHARMACOLOGICAL ACTIVITY. Swati Sharma, Ajay Deep kumar Jain, N.S.Gill, Rashmi Arora

STUDY ON SYNTHESIS OF IMIDES AND ITS VARIOUS PHARMACOLOGICAL ACTIVITY.

Swati Sharma, Ajay Deep kumar Jain, N.S.Gill, Rashmi Arora

International Journal of Natural Product Science 2012: Spl Issue 1:248.

Abstract(RBIP-248)

In organic chemistry, an imide is a functional group consisting of two carbonyl groups bound to nitrogen. These compounds are structurally related to acid anhydrides. The organic functional group called an imide contains two acyl groups are attached to NH or NR. Imides are compounds containing the structural grouping CO-NH-CO. Cyclic imides are a large class of compounds obtained by organic synthesis including several sub-classes (succinimides maleimide, glutarimide, phthalimides naphtalimides, and its derivatives). Synthetic methodology, as the building block of organic synthesis, continuously seeks for new reagents, better reaction conditions, and more efficient and selective methods. Imides derivatives are useful in the reactions involving condensation, alkylation, acylation, and cyclocondensation. Versatile method has been developed for synthesis of N-substituted imides. Various methods include conventional method, microwave assisted method, ionic liquid method and hydro (solvo) thermal technique. The synthesis of cyclic imides either by conventional methods or microwave irradiation is often carried out under harsh conditions thereby increasing byproduct formation. Currently, there are several conventional and microwave techniques to produce cyclic imides. Imide moiety is an integral part of structures of various important molecules such as fumaramidmycin, granulatimide, isogranulatimide, rebeccamycin, and thalidomide. These molecules are reported to exhibit wide variety of biological activities. Imide derivatives are a valuable group of bioactive compounds showing androgen receptor antagonists, anti-inflammatory, anxiolytic, antiviral, antibacterial, and antitumor properties.
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