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INDOLE NUCLEUS: A POTENTIAL PHARMACOPHORE IN MEDICINAL CHEMISTRY. Diksha and Viney Lather

INDOLE NUCLEUS: A POTENTIAL PHARMACOPHORE IN MEDICINAL CHEMISTRY.

Diksha and Viney Lather

International Journal of Natural Product Science 2012: Spl Issue 1:245.

Abstract(RBIP-245)

Indole nucleus is an aromatic heterocyclic organic compound having a bicyclic structure, consisting of a six-membered benzene ring fused to a five membered nitrogen-containing pyrrole ring. Compounds containing an indole ring are called indoles. The other name is 2, 3-Benzopyrrole, ketole. Indole nucleus and its substituted derivates exhibit broad range of biological activities such as Anti-microbial, Anti-bacterial, Xanthine oxidase inhibitor activity, Anti-inflammatory, Anti- tumour, Analgesic, CNS depressant, Anti-inflammatory, transquilizing, Antiaxiety, Anti-HIV, Anti-tumour, Anti-histaminic and Antimitotic activity. Several indole and its derivatives used in the therapy are like Indomethacin, Sumatriptan, Pindolol, Reserpine, Vincristine, Mitomycin, Dihyroindole, Ellepticine, Indol-3-yl-acetic acid, cholorofurazole, ditercalinium, isatins. 1-benzazole, an indole derivative is being used as antimicrobial. This review will be focusing on the recently synthesized indole subsitited derivatives possessing important potential biological activities.
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