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THERMOREVERSIBLE MUCOADHESIVE GELS AS PROMISING SYSTEM FOR NASAL DRUG DELIVERY: A REVIEW. Shailja singh, Kanupriya, S.L.Hari kumar

THERMOREVERSIBLE MUCOADHESIVE GELS AS PROMISING SYSTEM FOR NASAL DRUG DELIVERY: A REVIEW.

Shailja singh, Kanupriya, S.L.Hari kumar

International Journal of Natural Product Science 2012: Spl Issue 1:238.

Abstract(RBIP-238)

Almost 40% of active Pharmaceutical ingredients have low oral bioavailability, high hepatic first-pass metabolism and also less competent in crossing the blood brain barrier for brain targeting through oral delivery. Various systems are introduced to conquer this problem as: nasal spray, gels, emulsions, droplets, suspensions, powders and thermo reversible mucoadhesive gels etc. Thermo reversible mucoadhesive gels have capable results in nasal drug delivery thus have been extensively explored. Thermo reversible mucoadhesive gels converts in gel in nasal cavity when administered at body temperature with suitable gel strength, results in increase of the residence time in nasal cavity. These formulations contain thermo reversible polymers (Pluronic F127 or Poloxamer) and mucoadhesive polymers. Thermo reversible polymers are a novel state of matter having both solid and liquid like properties which can be delivered as a fluid and solidifies within the body’s microenvironment where the temperature is higher than the sol-gel transition temperature. These formulations have the advantage to prevent the anterior leakage of dosage form, mask the taste impact, enhances the nasal bioavailability. Thermoreversible gels are formulated by two methods: simple stirring and cold method. This abstract presents an overview of Thermo reversible mucoadhesive gels as promising approach to effectively reduce the problem of low oral bioavailability of drugs.
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