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AQUASOMES: PROMISING CARRIERS FOR PROTEIN PHARMACEUTICALS. Karan Sharma, Rajesh Kumar, Jatinderjot Kaur Kehal, Chander Mohan

AQUASOMES: PROMISING CARRIERS FOR PROTEIN PHARMACEUTICALS.

Karan Sharma, Rajesh Kumar, Jatinderjot Kaur Kehal, Chander Mohan

International Journal of Natural Product Science 2012: Spl Issue 1:215.

Abstract(RBIP-215)

Aquasomes are one of the most advanced drug delivery systems for the delivery of peptide/protein pharmaceuticals. These are nanoparticulate carriers which are three layered self-assembled structures. They comprise the central solid nanocrystalline core coated with polyhydroxy oligomers onto which biochemically active molecules are adsorbed. The solid core provides the structural stability and carbohydrate coating acts as dehydroprotectant thereby stabilizes the biochemically active molecules. Being able to maintain the conformational integrity of bioactive molecules, aquasomes are proposed as a carrier system for delivery of protein and peptide based pharmaceuticals. The delivery system has been successfully utilized for the delivery of insulin, hemoglobin and various antigens. Oral delivery of enzymes like serratiopeptidase has also been achieved. The present discussion explains the problems faced in the delivery of clinically important peptides and presents aquasomes as a reliable approach to troubleshoot them.
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