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THERAPEUTIC DRUG MONITORING: AN OVERVIEW. Ravinder Singh Negi, Ashok Kumar, S.M.Hassan, Sunil Kumar, A.C.Rana

THERAPEUTIC DRUG MONITORING: AN OVERVIEW.

Ravinder Singh Negi, Ashok Kumar, S.M.Hassan, Sunil Kumar, A.C.Rana

International Journal of Natural Product Science 2012: Spl Issue 1:206.

Abstract(RBIP-206)

Therapeutic drug monitoring (TDM) integrates knowledge of Pharmacokinetics and Pharmacodynamics by measuring drug concentrations in blood to optimise and individualise the chosen therapy. This approach has been of great value, particularly when there is a relationship between blood concentration and clinical effect but no simple clinical parameter is available, or where the drug has a narrow therapeutic index, in order to document drug-drug interactions and, not least, to establish drug adherence. TDM is a system of quality assurance of a drug management system, aiming to give the right drug to the right patient in the right dose in order to obtain the right effect. Over the years TDM has lost its importance because physicians have been handling drug dosing fairly well without TDM , it resulted in adverse events, example those following Abacavir administration.

A pharmacist has role to play in management of measured plasma concentration, dose history, PK dose advice, interpretation and advice to the treating physician. Assays by robots allow the measurement of large numbers of samples. Knowledge of pharmacotherapy, bio analysis and PK should be integrated into daily clinical pharmacy routines and give support and better drug treatment to all patients, using the new concept of TDM.
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