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UTILIZATION OF HERBALS AS SUPERDISINTEGRANT. Sunny Sharma, Atul K. Gupta

UTILIZATION OF HERBALS AS SUPERDISINTEGRANT.

Sunny Sharma, Atul K. Gupta

International Journal of Natural Product Science 2012: Spl Issue 1:181.

Abstract(RBIP-181)

For fast dissolving tablets which need rapid disintegration, the inclusion of the right disintegrant is a prerequisite for optimal disintegration and dissolution. The formulations that do not use disintegrants are believed to impart their disintegrating action through porosity and capillary action, generally used in the amount up to 10% by weight and this tablet porosity provides pathways for the penetration of fluid into tablets but have problems in hardness and friability with very poor industrial applicability. Superdisintegrants are used to improve the efficacy of solid dosage forms which is achieved by decreasing the disintegration time which in turn enhances drug dissolution rate. Superdisintegrants are widely used in direct compression and wet granulation applications. Superdisintegrants is believed to be act by swelling in contact with water; the adhesiveness of other ingredients in a tablet is overcome causing the tablet to fall apart. Salicornia fruticosa powder was effective as disintegrants in low concentrations (5%) in the fast dissolving and Gellan gum is an anionic polysaccharide of linear tetrasaccharides, derived from Pseudomonas elodea having good superdisintegrant property similar to the modified starch and celluloses. Xanthan Gum derived form Xanthomonas campestris is official in USP with high hydrophilicity and low gelling tendency. It has low water solubility and extensive swelling properties for faster disintegration. Locust beam gum has been used as a superdisintegrant in the formulation of the Nimesulide Orodispersable tablets. Thus there is huge potential of herbals to be utilized as disintegrating agents in pharmaceutical formulations.
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