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ANTIDIABETIC ACTIVITY OF EMBLICA OFFICINALIS SEED EXTRACT IN STREPTOZOTOCIN INDUCED TYPE-2 DIABETES MELLITUS IN RAT. Parminder Nain, Vipin Saini, and Sunil sharma

ANTIDIABETIC ACTIVITY OF EMBLICA OFFICINALIS SEED EXTRACT IN STREPTOZOTOCIN INDUCED TYPE-2 DIABETES MELLITUS IN RAT.

Parminder Nain, Vipin Saini, and Sunil sharma

International Journal of Natural Product Science 2012: Spl Issue 1:135.

Abstract(RBIP-135)

Objective - Emblica officinalis commonly known as amla is a medicinal plant, used in Ayurveda for treating various diseases, one of which is diabetes mellitus. In present study, we evaluated the antidiabetic property of Emblica officinalis seeds extract.

Method - Diabetes mellitus was induced with streptozotocin (45 mg/kg b.w.) in 0.1 M citrate buffer (pH 4.5)). Male albino Wistar rats (n=42) were divided into seven equal groups. Rats with moderate diabetes having hyperglycemia (that is, with blood glucose of 250 - 400 mg/dl) were taken for the experiment. Diabetic rats were orally administered methanolic seeds extract of Emblica officinalis (100, 200, 300 and 400 mg/kg, p.o.), glibenclamide (1mg/kg, p.o.) and vehicle for 45 days. The effect of Emblica officinalis seeds extracts on serum glucose, insulin and biochemical parameters such as total protein, Serum creatinine, and Serum Urea, SGOT, SGPT and lipid profile were examined in control and extracts treated diabetic rats.

Results- Oral administration of methanolic seeds extract of Emblica officinalis for 45 days significantly (P<0.05) reduced blood sugar and increase insulin level and also reverse all above biochemical parameters at dose dependent manner. The histological studies of the endocrine region of pancreas of diabetic animals revealed that shrinkage of β cells of islets of langerhans. The methanolic extracts treated animals’ revealed restoration of β-cells at higher dose level.

Conclusion - These findings provide in vivo evidence that methanolic seeds extract of Emblica officinalis possess significant antidiabetic activity in streptozotocin-induced type-2 diabetes mellitus in rats.
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