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DRUG DISCOVERY. Ritika Kalia,Pooja Joshi,Mohd. Shahnaz,D.N. Prasad

DRUG DISCOVERY.

Ritika Kalia,Pooja Joshi,Mohd. Shahnaz,D.N. Prasad

International Journal of Natural Product Science 2012: Spl Issue 1:129.

Abstract(RBIP-129)

In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered or designed. In the past most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery. As our understanding of disease has increased to the extent that we know how disease and infection are controlled at the molecular and physiological level, scientists are now able to try to find compounds that specifically modulate those molecules, for instance via high throughput screening. Even more recently, scientists have been able to understand the shape of biological molecules at the atomic level, and to use that knowledge to design drug candidates. Novartis drug discovery and development efforts begin and end with the patient. Our R&D efforts are guided by two principles:
: Do we understand the underlying mechanism or cause of the disease?
: Does this disease represent a significant unmet medical need in patients?

If the answer to both questions is "yes," then we develop a research program aimed at better understanding the disease and finding an effective chemical or biologic based medicine. The process of drug discovery involves the identification of candidates, synthesis, characterization, screening, and assays for therapeutic efficacy. Once a compound has shown its value in these tests, it will begin the process of drug development prior to clinical trials. It includes Drug target, Screening and design, Historical background, Nature as source of drug, Chemical diversity of Natural products, Natural products discovery: Screening and structure elucidation.
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