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REVIEW OF THE 2-AMINO SUBSTITUTED BENZOTHIAZOLES. Kumar, R.Puneet Yadav, R.Gupta, G.D.

REVIEW OF THE 2-AMINO SUBSTITUTED BENZOTHIAZOLES.

Kumar, R.Puneet Yadav, R.Gupta, G.D.

International Journal of Natural Product Science 2012: Spl Issue 1:118.


Abstract(RBIP-118)

Heterocyclic compound analogues and derivatives have attracted strong interest due to their biological and pharmacological properties. Benzothiazoles are bicyclic ring system. Amino-benzothiazoles constitute an important class of compounds. The 2-amino substituted benzothiazoles was synthesized by reaction of substituted aniline and potassium thiocyanate in the presence of glacial acetic acid and bromine. In recent year heterocylic compounds analogues and derivatives have attracted strong interest due to their useful biological and pharmacological properties. The small and simple benzothiazole nucleus is present in compounds involved in research aimed at evaluating new products that possess biological activities like anti-microbial, anthlemintic, anti-leishmanial,anti-convulsant and anti-inflammatory. The structures of compounds were elucidated by spectral studies. Purity of compounds was checked by TLC. Melting points were determined by capillaries method.IR spectra are recorded on FTIR (Schimadazu-84005) spectrophotometer using nujol mull technique. 1HNMR spectra are recorded on spectrophotometer (Bruker AMX) at 500MHz, using TMS as internal reference. LCMS was carried out to get exact molecular weight and screened for antibacterial activity against various strains of S.aureus, S.epidermidis, E.coli, P.aeruginosa, Bacillus subtillis for their microbiological activities and antifungal activity against Candida albicans, Rhizopus oryzae and Aspergillus niger. The present review focuses on different methods of substituted benzothiazoles with potential activities that are now in development.
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