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SUPERPOROUS HYDROGEL COMPOSITES-A NEW GENERATION OF HYDROGELS. ALISHA MEHTA, DEEPTI PANDITA

SUPERPOROUS HYDROGEL COMPOSITES-A NEW GENERATION OF HYDROGELS.

ALISHA MEHTA, DEEPTI PANDITA

International Journal of Natural Product Science 2012: Spl Issue 1:81.

Abstract (RBIP-81)

Conventional nonporous hydrogels have certain limitations such as slow swelling, low loading capacities and ultimately dissolve over time in the presence of sufficient water or the swelling medium which restrict their use in effective drug delivery. Also they are currently commercially available in powder form (small particle size) as particle size inversely affects the rate of water absorption. These limitations can be overcome by utilizing superporous structures called superporous hydrogels (SPH) in which water absorption is dominated by a capillary or wicking mechanism. High degree of swelling, rapid swelling and mechanical strength are met, by surface- crosslinked hydrogel particles. They swell fast to equilibrium size in minutes due to water uptake by capillary wetting through numerous interconnected open pores. SPH preparation involves two steps viz. polymerization and foaming. Certain ingredients including initiators, crosslinkers, foam stabilizers, foaming aids and foaming agents are used. Mechanical strength of the highly swollen SPH is increased by adding a composite material i.e. super porous hydrogels composite (SPHC) e.g. carbopol 934P, Ac-Di-Sol, which is a hollow microparticle of a hydrophilic polymer. The presence of hollow microparticles results in physical entanglements of polymer chains around the microparticles. This essentially increases the effective crosslinking density without making the superporous hydrogels too brittle. Drug delivery systems based on SPH and/or SPHC for human insulin, N-α-benzoyl-L-arginine ethylester , octreotide , buserelin and desmopressin have been reported. An instant swelling hydrogel has also shown potential application for peroral intestinal peptide and protein absorption. They can also be used in diet control area,for the people who desire to reduce the volume of food they take. Bioadhesive, as well as floating SPHC drug-delivery system is also promising for stomach specific delivery.
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