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EMULGELS: A NOVEL APPROACH TO TOPICAL DRUG DELIVERY. Sheefali Mahant

EMULGELS: A NOVEL APPROACH TO TOPICAL DRUG DELIVERY.

Sheefali Mahant

International Journal of Natural Product Science 2012: Spl Issue 1:69.

Abstract (RBIP-69)

Topical drug delivery systems allow localized administration of the drug anywhere in the body through ophthalmic, vaginal, skin and rectal routes. Topical formulations encompass a wide variety of formulations intended for cosmetic or dermatological application, to healthy as well as diseased skin. Drugs may be administered for localized or systemic effect. Topical preparations can be formulated with varying physicochemical properties, as solid, semisolid or liquid. In recent years, emulgel formulations have been developed for a number of drugs intended for topical or systemic action. An emulgel is basically a gellified emulsion. It is prepared by mixing an oil-in-water type or water-in-oil type emulsion with a gelling agent. This approach has been applied to numerous drug categories, viz. anti-fungal agents, anti-inflammatory agents, anti-acne agents, corticosteroids, etc. Emulgel formulations offer several advantages over the conventional topical formulations, like creams, ointments, lotions and powders. Emulgels allow dual control of dug release from the formulation, i.e. emulsion and gel. Incorporation of the emulsion into a gel enhances its stability. It is well suited to the administration of hydrophobic drugs. Oil-in-water emulsions may be formulated where a water washable base is intended, eg. for cosmetic purposes, whereas, water-in-oil type emulsions are a good choice for the treatment of dry skin and emollient application. To conclude, emulgels have offered a novel approach for the topical administration of a wide variety of therapeutic agents and results of the research carried out in the past decade have revealed that they promise an enhanced therapeutic efficacy as well as stability, as compared to the conventional topical formulations
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