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DESIGN AND DEVELOPMENT OF CEFDINIR NIOSOMES FOR ORAL DELIVERY. Saurabh Bansal, Chandan Prasad Kashyap, SL Harikumar

DESIGN AND DEVELOPMENT OF CEFDINIR NIOSOMES FOR ORAL DELIVERY.

Saurabh Bansal, Chandan Prasad Kashyap, SL Harikumar

International Journal of Natural Product Science 2012: Spl Issue 1:68.

Abstract (RBIP-68)

An ideal drug delivery system delivers drug at rate dictated by the need of the body over the period of treatment and it channels the active entity solely to the site of action. Niosomes are non-ionic surfactant vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or other lipids. The niosomal system has a number of advantages thus helps to improve the therapeutic performance of the drug molecules by delayed clearance from the circulation, protecting the drug from biological environment and restricting effects to target cells. It also improves oral bioavailability of poorly absorbed drugs. Since cefdinir has low water solubility and oral bioavailability and it comes under third generation cephalosporins showing broad spectrum activity, thus niosomal formulation of this drug can solve the purpose. The proposed research is based on the optimization of novel controlled release vesicular and provesicular oral drug delivery system which can be able to improve oral bioavailability as well as the controlled release for the drug for longer duration of time. The provesicular approach further improves stability and the process will be controlled by formulation parameters to provide good bases of oral drug delivery system.
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