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CURRENT APPROACHES IN THE DRUG DELIVERY THROUGH NAIL. Charanjeet Kaur, Rajesh Kumar, Chander Mohan

CURRENT APPROACHES IN THE DRUG DELIVERY THROUGH NAIL.

Charanjeet Kaur, Rajesh Kumar, Chander Mohan

International Journal of Natural Product Science 2012: Spl Issue 1:56.

Abstract (RBIP-56)

The present discussion explores the difficulties in penetration of drug across nail plate and enhancement of bioavailability of antifungal drug. These difficulties occur due to lack of understanding of both barrier properties of nail and formulation to achieve the enhanced ungual delivery. Mainly, nail plate which is the hard part of the nail is responsible for penetration of drug across it. In order to successfully deliver the drug across the nail, it is necessary to know about the anatomy and physiology of nail barrier. Diseases related to nail like Onchomycosis, Nail Psoriasis, Yellow Nail Syndrome and many more are being cured using antifungal drugs and medicated lacquers. Existing oral formulations typically contain large doses of active ingredient and cause several side effects or systemic toxicity in the liver, so are not preferred. Current topical treatments have limited therapeutic effectiveness being unable to sufficiently penetrate the nail plate to transport sufficient amount of antifungal drug. To enhance the permeability of the antifungal drugs, it is necessary to know about the various approaches of nail drug delivery like topical application, chemical penetration enhancement, physical penetration enhancement etc. By using this information, we can more effectively utilize drug delivery approaches to maximize the effectiveness of active pharmaceutical ingredient (API) i.e. getting the right amount of the drug to the right place at the right time.
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