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MASKING THE BITTERNESS OF LIVOCETIRIZINE DIHCL AND FORMULATE ITS MDTS. Atul K. Gupta, Ashok Kumar, D N Mishra

MASKING THE BITTERNESS OF LIVOCETIRIZINE DIHCL AND FORMULATE ITS MDTS.

Atul K. Gupta, Ashok Kumar, D N Mishra

International Journal of Natural Product Science 2012: Spl Issue 1:55.


Abstract(RBIP-55)

Oral administration of bitter drugs with an acceptable degree of palatability is a key issue for health care providers especially for pediatric and geriatrics patients. Levocetirizine diHCl, a third-generation non-sedative antihistamine is active enantiomer of cetirizine with very bitter taste. The purpose of this research was to mask the bitter taste of levocetirizine diHCl and formulation of Mouth dissolving tablet. Taste masking of levocetirizine diHCl was carried out using drug resin complexation method by addition of resin in different ratio. The taste masking was evaluated on human volunteers. Complex was also evaluated for percentage entrappment efficiency. The MDTs were prepared using taste masked complex of drug. In our study, different ratio of drug resin complexes show different taste reported by volunteeres. In drug resin ratios more then 1:2 completely mask the taste of levocetirizine diHCl. The prepared MDTs of this complex shows more than 90% drug release within 10minutes. In conclusion, resin completely mask the taste of levocetirizine diHCl because complexed drug resinate does not release drug in mouth due to scarcity of exchangeable ions in the saliva and when this complex comes in contact with GIT fluids (at acidic pH ), complex is broken down quickly and drug is release.
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