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TOOLS IN DRUG DEVELOPMENT: MICROCHIP TECHNOLOGY Mahesh, Pradeep Kumar, Tarun Gugnani, Mukesh, Mamta Seth

TOOLS IN DRUG DEVELOPMENT: MICROCHIP TECHNOLOGY

Mahesh, Pradeep Kumar, Tarun Gugnani, Mukesh, Mamta Seth

International Journal of Natural Product Science 2012: Spl Issue 1:49.

Abstract (RBIP-49)

Significant advances have been made in the development of micro-scale technologies for biomedical and drug discovery applications. Advances in micro fabrication technology have made an entirely new type of drug delivery device possible. Microchip-based implantable drug delivery devices allow localized delivery by direct placement of the device at the treatment site, delivery on demand (emergency administration, pulsatile, or adjustable continuous dosing), programmable dosing cycles, automated delivery of multiple drugs, and dosing in response to physiological and diagnostic feedback. Proof-of-principle experiments have shown that silicon microchips have the ability to store and release multiple chemicals on demand. Future integration of active control electronics, such as microprocessors, remote control units, or biosensors, could lead to the development of a 'pharmacy on a chip,' ie 'smart' microchip implants or tablets that release drugs into the body automatically when needed. The first generations of microfluidics-based analytical devices has been designed and are already functional. Microfluidic devices offer unique advantages in sample handling, reagent mixing, separation and detection. Microchips have been successfully implanted for certain skin allergies and studies are being carried out for the treatment of osteoporosis and for the delivery of highly concentrated proteins and peptides.
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