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CHRONOTROPIC DRUG DELIVERY SYSTEM: A NOVEL APPROACH. Tarun Gugnani, Virender Sachdeva ,Vineet Kumar ,Mamta Seth

CHRONOTROPIC DRUG DELIVERY SYSTEM: A NOVEL APPROACH.

Tarun Gugnani, Virender Sachdeva ,Vineet Kumar ,Mamta Seth

International Journal of Natural Product Science 2012: Spl Issue 1:47.

Abstract (RBIP-47)

Advances in chronobiology, chronopharmacology and requirement of an appropriate technology to deliver the drug at specific time and site resulted into novel type of drug delivery systems, ‘chronotropic or pulsatile drug delivery systems”. The principle rationale behind designing these delivery systems is to release the drug at desired time as per the pathophysiological need of disease, resulting in improved patient therapeutic efficacy and compliance. As the name suggests, these systems are meant for chronopharmacotherapy, treatment of those diseases that are caused due to circadian changes in body. These systems are developed when zero order drug release is not desired. Pulsatile drug delivery systems are designed to release certain amount of drug within a short period of time, immediately after a predetermined lag time. Diseases wherein chronotropic systems are promising include asthma, peptic-ulcer, cardiovascular diseases, arthritis, attention-deficit syndrome in children and hypercholestemia etc. Chronopharmaceutics also plays a major role in pain control therapies. An ideal chronotropic system should be self regulating, taken any time and should take environmental factors in account (e.g. awake– sleep, light–dark, activity–rest status). Chronopharmaceutics will certainly improve patient outcome and optimize disease management in the future.
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