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ELASTIC LIPOSOMES-A RECENT APPROACH FOR TRANSDERMAL DRUG DELIVERY Manvir Aujla, Ravi Kumar, Nimrata Seth, Rajni Arora, A CRana

ELASTIC LIPOSOMES-A RECENT APPROACH FOR TRANSDERMAL DRUG DELIVERY.

Manvir Aujla, Ravi Kumar, Nimrata Seth, Rajni Arora, A C Rana

International Journal of Natural Product Science 2012: Spl Issue 1:46.

Abstract (RBIP-46)

The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. But it has got its own limitations as well- inability to transport large molecules, inability to overcome the barrier properties of stratum corneum and many more. Recently, various strategies have been used to augment the transdermal delivery of bioactives. Mainly, they include iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and vesicular system (liposomes, niosomes, elastic vesicles such as ethosomes and transfersomes). Among these strategies transferosomes appear promising. Transferosomes are made up of a phospholipids component along with a surfactant mixture. The ratios of individual surfactants and total amount of surfactants control the flexibility of the vesicle. The uniqueness of this type of drug carrier system lies in the fact that it can accommodate hydrophilic, lipophilic as well as amphiphilic drugs. Transfersomes differ vastly from liposomes and niosomes in that they are much more flexible and adaptable. Transfersomes, are the only tested colloidal system that can transport even large macromolecules spontaneously through the skin in immunologically active form. Thus, smaller than their own diameter, these Elastic Liposomes (transferosomes) can improve the therapeutic effectiveness of the bioactive molecule via skin.
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