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TRANSDERMAL DRUG DELIVERY SYSTEM: AN OVERVIEW. Kiran Bala, A.C.Rana, Seema Saini, Neha Soni, Kavita Attri

TRANSDERMAL DRUG DELIVERY SYSTEM: AN OVERVIEW.

Kiran Bala, A.C.Rana, Seema Saini, Neha Soni, Kavita Attri

International Journal of Natural Product Science 2012: Spl Issue 1:45.


Abstract (RBIP-45)

The transdermal route of drug delivery has attracted researchers due to many biomedical advantages such as sustained release, reduced intensity of action, etc. It is the system in which the delivery of the active ingredients of the drug occurs by the means of skin. It involves drug transport to viable epidermal or dermal tissues of the skin for local therapeutic effect while a major fraction of drug is transported into the systemic circulation. The adhesive of the TDDS is critical to the safety, efficacy and quality of the product. Topical administration of therapeutic agents offers many advantages over conventional oral drug delivery. Many advantages of transdermal drug delivery are limitation of hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug. Drugs with very low or high partition coefficient fail to reach blood circulation .Various parameters which affect the transdermal absorption of drugs through iontophoresis like drug concentration, polarity of drugs, pH of donor solution, presence of co-ions, ionic strength, electrode polarity etc.

Keywords: transdermal patch, partition coefficient, adhesive.
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