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NANOPHARMACEUTICALS: A REVIEW. JS Dua, Balwinder Kaur, Shikha, Mandeep, D N Prasad

NANOPHARMACEUTICALS: A REVIEW

J.S. Dua, Balwinder Kaur, Shikha*, Mandeep, D.N. Prasad

International Journal of Natural Product Science 2012: Spl Issue 1:41.

Abstract (RBIP-41)

Nanopharmaceuticals are a relatively new class of therapeutic substances containing nanomaterials that often have unique nanoproperties (physiochemical properties) due to their small size (compared with their bulk phase counterparts), a high surface – to – volume ratio and the possibility of modulating their properties: nanoparticles intended for a broad spectrum of clinical therapeutic applications. They have the potential to target a particular organ or tissue site. Nanopharmaceuticals present normal reformulation opportunities for active agents that were insoluble or could not be targeted to the specific site of the body where they were needed. Those therapeutic agents that were previously unsuitable for traditional oral or injectable drug formulations can now be ‘nanoformulated’ for site specific delivery due to superior pharmacokinetics, pharmacodynamics and active interacellular delivery this approach has the ability to reduce toxicity and enhance bioavailability, improving, efficacy and patient, compliance. It can also increase drug half life by reducing immunogeneicity and diminishing drug metabolism. It has ability to extend the economic life of proprietary drugs as a result, they have the potential to affect during commercialization and the health care landscape. In the present article the advances in the nanopharmaceuticals including nanoparticulates, nanoemulsions, liposomes, micelles and dendrimers are outlined. Large scale manufacturing and costs of nanomedicines are also important issues to be addressed during development for clinic indication. Hopefully, this will soon represent a strategy for making cheaper and faster, more efficacious medicines.
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