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GASTRORETENTIVE DRUG DELIVERY SYSTEM: AN OVERVIEW. Reena Sharma, AC Rana, Nimarata Seth, Moni Ranaut

GASTRORETENTIVE DRUG DELIVERY SYSTEM: AN OVERVIEW.

Reena Sharma, AC Rana, Nimarata Seth, Moni Ranaut

International Journal of Natural Product Science 2012: Spl Issue 1:39.

Abstract (RBIP-39)

Floating Drug delivery system are designed to prolong the gastric residence time after oral administration, at particular site and controlling the release of drug especially useful for achieving controlled plasma level as well as improving bioavailability Several approaches are Currently being used to prolong the GRT, including floating drug delivery systems (FDDS)Also known as hydro dynamically balanced systems (HBS), swelling and expanding systems, High-density systems, and other delayed gastric emptying devices . In order to understand various physiological difficulties to achieve gastric retention, we have summarized important factors controlling gastric retention. Afterwards, we have reviewed various gastro retentive approaches designed and developed until now, i.e. high density (sinking), floating, bio- or mucoadhesive, expandable, unfold able, super porous hydro gel and magnetic systems. Finally, advantages of gastro retentive drug delivery systems were covered in detail. To avoid this problem, various efforts have been made to prolong the retention time of drug delivery system. In this review, we will discuss about the various approaches to produce gastro retention of drug delivery system, with special emphasis to floating inSitu gel system for stomach specific drug delivery.

Keywords: gastro retentive, mucoadhesive, residence time.
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