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PARTICULATE DELIVERY SYSTEM OF PROTEINS. AnkitaKashyap, A.C.Rana, Nimrata Seth, Anjana Thakur

PARTICULATE DELIVERY SYSTEM OF PROTEINS

AnkitaKashyap, A.C.Rana, Nimrata Seth, Anjana Thakur

International Journal of Natural Product Science 2012: Spl Issue 1:30.

Abstract (RBIP-30)

The success of protein as a therapeutic agent depends on developing a formulation in which the protein structure, its activity and delivery is maintained during shipping and long term storage. Proteins are complex challenging molecules for developing drug delivery system from a formulation perspective. The purpose of applying an injectable particulate delivery system for protein is to reduce the number of injections, increase patient compliance and to decrease the unwanted side effects. The complex drug delivery system of proteins is an alternative to conventional formulation of same in which the protein is in suspensionform, in an aqueous solution or is either lyophilized. Some proteins require controlled release while the other may require immediate pulsed or sustained release. Release can be obtained with particulate delivery system like microspheres, hydrogels, liposomes, emulsions etc. The incorporation of protein in the particulate system is a challenge and hence exemplified by water in oil emulsion. In present review, the particulate delivery of protein are presented and discussed.

Keywords: Drug delivery, Water in oil emulsion, Protein system
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