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ORAL PROTEIN DELIVERY: CURRENT STATUS AND EMERGING TRENDS. Chandan Sharma, A.C Rana,Gurpreet Singh, Baibhav Joshi, Vikas Singla.

ORAL PROTEIN DELIVERY: CURRENT STATUS AND EMERGING TRENDS.

Chandan Sharma, A.C Rana,Gurpreet Singh, Baibhav Joshi, Vikas Singla.

International Journal of Natural Product Science 2012: Spl Issue 1:29.

Abstract (RBIP-29)

Oral delivery of protein drugs is a highly attractive approach because of its high patient compliance. But protein drugs are currently used as parenteral formulations because of their poor oral bioavailability. Development of an effective oral delivery system for proteins requires a systematic understanding of their physicochemical properties, such as molecular weight, hydrophobicity, ionization constants, and pH stability, as well as biological barriers that restrict protein and peptide absorption from the gastrointestinal(GI) tract, including pH variability, enzymatic degradation, and membrane efflux. Various strategies explored for enhancing the bioavailability of orally administered proteins include amino acid backbone modifications, formulation approaches, chemical conjugation of hydrophobic or targeting ligand, and use of enzyme inhibitors, mucoadhesive polymers, and absorption enhancers. Numerous delivery systems for oral protein delivery have been actively developed, especially by pharmaceutical companies, in a optimism to make them clinically useful. Some of these technologies are BioORAL, Oral-Lyn, Orasome, Oradel, etc. In developing oral protein formulations in future, one needs to consider developing new biomaterials that can be more effectively protect and deliver protein drugs.

Keywords: Oral delivery, bioavailability, enzyme inhibitors, mucoadhesive polymer
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