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NIOSOMES AS A NOVEL DRUG DELIVERY CARRIER Neha Soni, A.C.Rana, Seema Saini, Kavita Attri, Kiran Bala

NIOSOMES AS A NOVEL DRUG DELIVERY CARRIER

Neha Soni, A.C.Rana, Seema Saini, Kavita Attri, Kiran Bala

International Journal of Natural Product Science 2012: Spl Issue 1:27.

Abstract (RBIP-27)

In past considerable attention has been focused on the development of new drug delivery system. The formulation of vesicles as a tool to improve drug delivery has created a lot of interest amongst the scientist working in the area of drug delivery systems. Vesicular system such as liposomes, niosomes, transferosomes, pharmacosomes and ethosomes provide an alternative to improve the drug delivery. Niosomes (non-ionic surfactant vesicles) play an important role owing to their nonionic properties. Niosomes are microscopic lamellar structures formed on admixture of non-ionic surfactant of the alkyl or dialkylpolyglycerol ether class and cholesterol with subsequent hydration in aqueous media. Although structurally similar to liposomes, they offer several advantages over them (e.g. promising vehicle for drug delivery, being non-ionic; less toxic, improved therapeutic index of drug). The preparation methods are hand shaking method, bubble method, sonication method, microfluidisation, ethanol injection method and ether injection method. The main aim of development of niosomes is to control the release of drug in a sustained way, modification of distribution profile of drug and for targeting the drug to the specific body site.

Keywords: Pharmacosomes sonication, liposomes, microfluidisation,
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