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INTERPOLYELECTROLYTE COMPLEXES AS PROSPECTIVE CARRIERS IN CONTROLLED DRUG DELIVERY. Jasmeet Kaur, Amanpreet Kaur

INTERPOLYELECTROLYTE COMPLEXES AS PROSPECTIVE CARRIERS IN CONTROLLED DRUG DELIVERY.

Jasmeet Kaur, Amanpreet Kaur

International Journal of Natural Product Science 2012: Spl Issue 1:20.

Abstract (RBIP-20)

In the current scenario, polymers as carriers have revolutionized the drug delivery system. A more successful approach to exploit different properties of polymers in a solitary system is the complexation of polymers to form polyelectrolyte complexes. These complexes circumvent the use of chemical crosslinking agents, thereby reducing the risk of toxicity. The complex formed is generally applied in different dosage forms for formulating stable aggregated macromolecules. Number of factors affects the formation and stability of polyelectrolyte complex. Polyelectrolyte complexes have aroused as an emerging system to deliver drug at target sites, controlling release rate of drug and thereby prolonging the therapeutic action. They are used as coating films, for binding pharmaceutical products and in preparation of microcapsules. Complexation between selected natural and synthetic polymers and their applicability in nanoparticles, microparticles, buccal films, sponges and matrix type tablets have been investigated. This review emphasizes on polyelectrolyte complexes, their classification, formation, characterization and future perspectives in concern to optimal drug delivery. An extensive research is going on in the area of polyelectrolyte complexes. It is concluded that polyelectrolyte complexes have multiple applications in future in the field biotechnology, medicine, pharmaceutical technology and in the design of novel drug delivery system.
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