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GASTRORETENTIVE DRUG DELIVERY SYSTEM. Vishal Sharma, A. C. Rana, Gurpreet Singh, Nimrata Seth, Rajni Bala, Seema Saini.

GASTRORETENTIVE DRUG DELIVERY SYSTEM.

Vishal Sharma, A. C. Rana, Gurpreet Singh, Nimrata Seth, Rajni Bala, Seema Saini.

International Journal of Natural Product Science 2012: Spl Issue 1:15.

Abstract (RBIP-15)

Oral delivery of drugs is the most preferable route of drug delivery due to ease of administration, patient compliance and flexibility in formulation. The drug absorption in the gastrointestinal (GI) tract may be very short and highly variable in certain circumstances. One of the most feasible approach for achieving a prolong and predictable drug delivery profile in GI tract is to control the gastroretentive time (GRT) i.e. Gastroretentive dosage form (GRDFs) .Dosage forms available as gastric floating systems include tablets, capsules, granules and microspheres. Drugs that could take advantage of gastric retention include the drugs whose solubility is less in the higher pH of the small intestine than the stomach (e.g. chlordiazepoxide and cinnarizine), the drugs prone for degradation in the intestinal pH (e.g. Captopril and the drugs for local action in the stomach (e.g. misoprostol). Antibiotics, catecholamines, sedatives, analgesics, anticonvulsants, muscle relaxants, antihypertensives and vitamins can also be administered in HBS dosage form.

Keywords: Gastroretentive, microspheres, tablets, capsules.
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