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DRUG DELIVERY THROUGH SKIN BY LIPID VESICLES. Anjana Thakur, A.C.Rana, Nimrata Seth, Ankita Kashyap

DRUG DELIVERY THROUGH SKIN BY LIPID VESICLES.

Anjana Thakur*, A.C.Rana, Nimrata Seth, Ankita Kashyap

International Journal of Natural Product Science 2012: Spl Issue 1:13.

Abstract (RBIP-13)

The potential value of liposomes for topical therapy was first shown by Mezei and Gulasekharan in 1980.After years of investigation the lipid vesicles were developed as carriers for skin delivery of drugs.The lipid vesicles are still controversial class of dermal and transdermal carriers.Liposomes are lipid vesicles that enclose an aqueous component.They are also considered as phospholipids with or without some additives.The characteristic of bilayer liposomes are improved by addition of cholesterol which increases the microviscosity of the bilayer,further enhances membrane stability and increases rigidity of the vesicles.The mechanism by which the liposomes enhance skin delivery of drugs include penetration enhancing effect,the absorption effect,the intact vesicular skin penetration of liposome through the transappendageal route.The emphasis are also given for skin delivery of proteins and other macromolecules and also for transcutaneous immunization.The recent investigation and development has been with a new liposomal system that is propylene glycol embodying liposome(PG liposome)composed of phospholipid,propylene glycol and water.This article gives an overview of the lipid vesicles development for skin delivery of drugs with emphasis on recent advances in this field which include the deformable liposomes and ethosomes.

Keywords: liposomes, skindelivery, deformableliposomes, ethosomesmechanism.
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