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CHEWING GUM: A NEW APPROACH FOR ORAL DRUG DELIVERY. Baibhav Joshi, Madhu Sharma, Gurpreet Singh, Vikas Singla, Dr A.C Rana, Chandan Sharma.

CHEWING GUM: A NEW APPROACH FOR ORAL DRUG DELIVERY.

Baibhav Joshi, Madhu Sharma, Gurpreet Singh, Vikas Singla, A.C Rana1, Chandan Sharma1.

International Journal of Natural Product Science 2012:Spl Issue 1:12.

Abstract (RBIP-12)

Chewing gum has been used worldwide since ancient times when people experienced the pleasure of chewing a variety of gum-like substances. The introduction and subsequent success of nicotine chewing gum in the 1980s paved the way for a more general acceptance of chewing gum as a drug delivery system Chewing gums are mobile drug delivery systems. It is a potentially useful means of administering drugs either locally or systemically via, the oral cavity. The medicated chewing gum has through the years gained increasing acceptance as a drug delivery system. Several ingredients are now incorporated in medicated chewing gum, e.g. Fluoride for prophylaxis of dental caries, chlorhexidine as local disinfectant, nicotine for smoking cessation, obesity, xerostomia, motion sickness, acidity and specially diabetes, aspirin as an analgesic, and caffeine as a stay alert preparation. They contain one or more active substances which are released by chewing and are intended to be used for local treatment of mouth diseases or systemic delivery after absorption through the buccal mucosa.

Keywords- Prophylaxis, xerostomia, smoking cessation, chlorhexidine
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