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SURFACTANTS AS SKIN PERMEATION ENHANCERS FOR TRANSDERMAL DELIVERY. Samita Singla, S.L Hari kumar, Geeta Aggarwal.

SURFACTANTS AS SKIN PERMEATION ENHANCERS FOR TRANSDERMAL DELIVERY.

Samita Singla, S.L Hari kumar, Geeta Aggarwal.

International Journal of Natural Product Science 2012: Spl Issue 1: 10.

Abstract (RBIP-10)

The main aim of the present study is to develop transdermal drug delivery system of risperidone which can minimize the risk of major oral side effects and address the problems of poor compliance in patients. The strategy was formulation of eudragit based polymeric films to prepare transdermal patches by using non-ionic (Span-20), anionic (sodium lauryl sulphate) and cationic surfactant (benzalkonium chloride) as permeation enhancers. The interaction studies carried out by comparing the results of FTIR analyses for the pure drug, polymers and mixture of drug and polymers indicated no chemical interaction between drug and excipients. The patches were subjected to physicochemical, in vitro release and ex vivo permeation studies. On the basis of in vitro release performance, ERL 100: ERS 100 in the ratio of 3:2 was selected for incorporation of permeation enhancers. The permeation studies showed that formulation containing non ionic surfactant exhibited greatest cumulative amount of drug permeated. The optimized batch was assessed for skin irritation potential. The formulation containing non ionic surfactant as permeation enhancer was able to deliver drug up to 3 days at a flux equivalent to the high dose currently marketed oral product from the patch containing surface area 10 cm2 with no skin irritation.
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