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CYCLODEXTRINS: AN EXCIPIENT TOOL IN DRUG DELIVERY. Nasir Ali, Amanpreet Kaur, S L Harikumar.

CYCLODEXTRINS: AN EXCIPIENT TOOL IN DRUG DELIVERY.

Nasir Ali, Amanpreet Kaur, S L Harikumar.

International Journal of Natural Product Science 2012: Spl Issue 1: 8.

Abstract (RBIP-08)

Nearly 40% of the new chemical entities currently being discovered are poorly water soluble drugs, thus to enhance their efficacy is a challenging task in drug development. Aqueous solubility of any therapeutically active substance is a key property, as it governs dissolution, absorption and thus the in vivo efficacy of the drug. The proposed review on Cyclodextrins (CDs) explores its utility as useful functional excipients that have enjoyed widespread attention and use in the pharmaceutical industry. The bioadaptability and multi-functional characteristic of CDs make them capable of alleviating the undesirable properties of drug molecules in various routes of administration through the formation of inclusion complexes. Poor dissolution is a major problem of almost all BCS class II drugs, which leads to poor bioavailability. Such type of hosting with CDs helps in enhancing their aqueous solubility, dissolution, stability and bioavailability, thus proving CDs to be greatly applicable in the pharmaceutical, agrochemical, food and cosmetic industry. CDs can be used extensively as a polymer in NDDS like liposomes, nanoparticles and microspheres that can be expected to improve the therapeutic efficacy of drug and patient compliance. In future, CDs may solve various problems associated with drug delivery through complexation.
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