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MAGNETIC PILLS: ATTRACTIVE OPTION FOR DRUG DELIVERY. Rakhi, Nishal Suchitra, Sharma Swati, Malhotra Ritika, Kapoor Gunjan

MAGNETIC PILLS: ATTRACTIVE OPTION FOR DRUG DELIVERY.

Rakhi, Nishal Suchitra, Sharma Swati, Malhotra Ritika, Kapoor Gunjan

International Journal of Natural Product Science 2012: Spl Issue 1: 7.

Abstract (RBIP-07)

Objective: To formulate Magnetic pills for prolonged drug delivery.

Method: A magnet-based delivery system visualized by biplanar video fluoroscopy in vivo yields real time monitoring and control over the duration of GI residence of model magnetic pills in the small intestines of rats. It acts as a tool for investigating the GI site-specific absorption, therapeutic action and a critical step towards enabling clinical localization of magnetic pills. A computer controlled material testing device equipped with a load-cell that has a programmed feedback loop, constantly adjusting the position of the external magnet between upper and lower intermagnetic force bounds defined by the user. As a result, it is ensured that the GI tissue experiences the least amount of force possible that still retains the magnetic oral dose.

Conclusion: Safe and effective, monitored magnetic pill localization is a crucial step for investigating and producing new, site-specific therapies for the treatment of a wide range of diseases.
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