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PREVENTIVE AND INTERVENTIONARY EFFECTS OF LACIDIPINE IN STZ INDUCED DIABETIC NEPHROPATHY. Suruchi A , Singh J , Lal H

PREVENTIVE AND INTERVENTIONARY EFFECTS OF LACIDIPINE IN STZ INDUCED DIABETIC NEPHROPATHY.

Suruchi A , Singh J , Lal H

International Journal of Biochemistry & Biotech Science 2012; 1: 13-21

Abstract

Streptozotocin (STZ) induced diabetic nephropathy (DN) in rats was monitored by measuring urine volume, electrolytes, urinary proteins, blood urea and serum creatinine. Lacidipine (0.5 mg/kg, po) pretreatment as well as treatment (lacidipine started 10 weeks after STZ administration) failed to reduce urine volume and blood sugar levels in diabetic rats. Lacidipine increased electrolytes (Na+, K+) excretion in diabetic rats. However, in both preventive and interventionary study, lacidipine decreased blood urea and serum creatinine concentration. Thus, lacidipine prevents and ameliorates the STZ induced nephropathy changes in rats.

Key words: Lacidipine, STZ, diabetic nephropathy, Calcium channel blockers.
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