HIGH QUALITY SCIENTIFIC CONTENT,  ONLINE OPEN ACCESS,  GLOBAL SCIENTIFIC AUDIENCE,  COST EFFECTIVE, ANY ONE CAN DOWNLOAD REPRINTS 
Spreading knowledge

Google Scholar

Google Scholar

Archives

Back 

Toxicity Studies of the Crude Aqueous Stem bark extracts of Bridelia ferruginea in Albino Rats. Olarewaju OI , Oloyede OI, Ajayi OB, Ojo OA, Ajiboye BO

Toxicity Studies of the Crude Aqueous Stem bark extracts of Bridelia ferruginea in Albino Rats.

Olarewaju OI , Oloyede OI, Ajayi OB, Ojo OA, Ajiboye BO

International Journal of Pharmacology & Toxicology Science 2014; 4(1): 19-27

Abstract

The present study was aimed to investigate the LD50 of the crude aqueous stem bark extracts of Bridelia ferruginea and the effect of sub-chronic doses of the extract on liver and kidney function parameters of albino rats. The median lethal dose (LD50) of the aqueous stem bark extracts was calculated to be 3794.7 mg/kg body weight in albino rats while sub-chronic weight results showed a decrease in weight at higher dosage of 400mg/kg weight. From the results, there was significant (p<0.05) decrease in the total bilirubin and conjugated bilirubin levels of rats administered with B. ferruginea when compared with those of the control. Significant reduction in the serum albumin was observed in test groups with higher dose administration compared to the control group while the serum total protein also showed a significant reduction in test groups with higher dose administration compared to the control group. Also, there was a significant increase in liver AST and ALT activities in test groups. There was a significant increase in the activities (P<0.05) of AST in the kidney and the serum which might be caused by activation of enzymes synthesis in renal cells while ALT activities only increased in the Serum. It can be concluded that ingestion of aqueous extract of Bridelia ferruginea stem bark could confer protection on the liver tissues against injury, damage or disease and the extract may not be toxic at the doses investigated.


Key words: Albino rats, aqueous, LD50, stem bark extract of Bridelia ferruginea, sub-chronic toxicity, toxicological effect.
Attachments:
Time to create page: 0.23 seconds


Copyright © All rights reserved Science Instinct Publications sciipub.com