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COMPARATIVE EVALUATION OF PROPOFOL WITH THIOPENTONE ON LARYNGEAL REACTIVITY AND HEMODYNAMIC RESPONSE TO THE LARYNGEAL MASK (LMA) INSERTION IN ADULTS. Kawal Preet Singh, Navjot Kaur, Tarlochan S Punia, Ramandeep Singh, Ravi Kant Sharma

COMPARATIVE EVALUATION OF PROPOFOL WITH THIOPENTONE ON LARYNGEAL REACTIVITY AND HEMODYNAMIC RESPONSE TO THE LARYNGEAL MASK (LMA) INSERTION IN ADULTS

Kawal Preet Singh, Navjot Kaur, Tarlochan S Punia, Ramandeep Singh, Ravi Kant Sharma

International Journal of Pharmacology & Toxicology Science 2013; 3(5): 19-28

Abstract

The effects of propofol as a co-induction agent was compared with thiopentone, on the laryngeal reactivity and the hemodynamic response to Laryngeal Mask Airway (LMA) insertion in 100 healthy adult patients of American Society of Anesthesiologists (ASA) I of either sex, divided randomly into two groups of 50 each. Patients were premedicated with Tab. Diazepam 10 mg, two hours before surgery. Patients were induced with pentazocine 0.5 mg/kg, followed by midazolam 0.05 mg/kg, and then with propofol 2.5 mg/kg in group I, and with Thiopentone 4 mg/kg in group II. LMA was inserted after the induction, and the insertion characteristics like jaw relaxation, ease of insertion, coughing/bucking, hiccoughs or laryngeal spasm was noted. Hemodynamic parameters and SpO2 were recorded after LMA insertion for the next seven minutes. Good inserting conditions such as jaw relaxation, no requirement of drug supplementation were found significantly better with propofol than with thiopentone (p < 0.01). No difference was found regarding incidence of movement, coughing/bucking and hiccoughs between the two groups (p > 0.05). A few episodes of hypotension were observed in the propofol group after induction, but hemodynamic changes were less marked and of shorter duration with propofol after LMA insertion as compared with thiopentone.
Conclusion: Propofol co-induction provides superior conditions for LMA insertion with lesser hemodynamic response when compared to co-induction using thiopentone.

Keywords: Co-induction, laryngeal mask, propofol, thiopentone.
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