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DESIGN OF BIODEGRADABLE DRUG IMPLANTS FOR POST OPERATIVE SURGICAL CARE IN ANIMALS. K Purushotham Rao, Thimothy Maitho, Edward K Kamamia, Pratima S, Rajashree J Ingin, Anuradha G Patil, Niranjan GV, Sangmeshwar SS

DESIGN OF BIODEGRADABLE DRUG IMPLANTS FOR POST OPERATIVE SURGICAL CARE IN ANIMALS

K Purushotham Rao, Thimothy Maitho, Edward K Kamamia, Pratima S, Rajashree J Ingin, Anuradha G Patil, Niranjan GV, Sangmeshwar SS

International Journal of Pharmacology & Toxicology Science 2013; 3(5):1-7

Abstract

The concept of implantable therapeutic system for the long term therapy is a newer and developing area in drug research programmes. Post-operative surgical care in animals is most important for speedy recovery from injuries. The present work is focused on the preparation of sterile Diclofenac Sodium biodegradable sub dermal implants for the treatment of post-operative surgical care, in minor or major orthopedic surgeries in animals for local and immediate relief from pains and inflammation. Diclofenac Sodium was chosen as a model drug due to its wide spectrum of activity, low toxicity, and high efficiency against inflammation. Implant formulated by using plasticizer as Glycerin and Gelatin as a natural biodegradable polymer. The formulated implants were subjected for various physicochemical parameters like, thickness, drug content uniformity, weight variation, and IR studies. In-vitro drug release studies were carried out in pH 7.4 phosphate buffer. Stability studies of the formulations were also done at ambient temperature (30oC) for the period of three months as per ICH guideline. Significant physicochemical results were obtained and found to be within the limits of official standards. In-vitro release studies showed that implants hardened for 12 hours with formaldehyde were found to be sustained release of drug for a period of 6 days. The present study revealed that the prepared Gelatin based biodegradable implants will be useful for the treatment of post-operative surgical care in minor or major surgery and speedy recovery of animals.

Key words: Diclofenac Sodium, gelatin, sub-dermal implants.
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