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VOLTAGE GATED SODIUM CHANNELS IN NEUROPATHIC PAIN, THERE BLOCKERS AND POTENTIAL TREATMENT IN NEUROPATHIC PAIN. Gursimranpreet Singh, Ankit Dhir, Manveen Bhardwaj, Neha Machhan, Saurabh Sharma, RD Budhiraja

VOLTAGE GATED SODIUM CHANNELS IN NEUROPATHIC PAIN, THERE BLOCKERS AND POTENTIAL TREATMENT IN NEUROPATHIC PAIN.

Gursimranpreet Singh, Ankit Dhir, Manveen Bhardwaj, Neha Machhan, Saurabh Sharma, RD Budhiraja

International Journal of Pharmacology & Toxicology Science 2013; 3(4):1-9

Abstract

This review is aimed at discussing the role of voltage gated sodium channels [VGSC] in pain states. This involves establishing their role in pain states such as neuropathic pain, and which of these pain states the individual channels impact on and to what effect. Of the various subtypes mainly 4 subtypes are believed to be actively involved in the neuropathic pain that is NaV 1.3, NaV 1.7, NaV 1.8 and NaV 1.9. These 4 subtypes are expressed on peripheral nociceptor neurons involved in the pain signaling. Blocking of these subtypes by subtype specific drugs may prove to be useful in controlling the neuropathic pain states

Keywords: Neuropathic pain, nociceptor, sodium channels.
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