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A STUDY ON USE OF ANTIBIOTICS, ANTIBIOTICS RESISTANCE AND EARLY INDICATOR OF SEPSIS. Turkane Dhanush Ram, Satapathy Trilochan, Roy Amit, Banafar Alisha, Bhairam Monika, Shelgaonkar Jayant R, Prabhu Manoj Shankar, Nirmal Chandu Himanshu

A STUDY ON USE OF ANTIBIOTICS, ANTIBIOTICS RESISTANCE AND EARLY INDICATOR OF SEPSIS.

Turkane Dhanush Ram, Satapathy Trilochan, Roy Amit, Banafar Alisha, Bhairam Monika, Shelgaonkar Jayant R, Prabhu Manoj Shankar, Nirmal Chandu Himanshu

International Journal of Pharmacology & Toxicology Science 2013; 3(2): 15-31

Abstract

This study was carried out to collect relevant demographic information, antibiotics prescribing pattern and the common organism isolated including their antibiotics sensitivity patterns. A prospective observational study was carried out over a 3 month period (1 Dec. to 29 Feb.) in intensive care unit at the Aditya Birla Memorial Hospital, Pune (Maharastra). Total 501 patients were observed out of which 425 patients were on Antibiotic prescription. In 425 patients empirical therapy was applied and out of which 311 (73.2%) patients recovered fast. The patients were discharged and shifted to their prospective wards. Out of 425 patients, 274 patients shifted to respective wards/unit in just 3 days due to empirical therapy and the average stay duration was 3-4 days. During the study, most commonly found organism was gram negative than gram positive and fungi. The prevalence of organisms in specimen was found to be 23.53% (116 patients). .During the study, antibiotics like Linezolid, Tigecycline, Vancomycin and Amikacin were mostly sensitive to gram positive organisms (90-100%). However, antibiotics like ampicillin, amoxicillin and ciprofloxacin showed maximum resistance and Drugs belonging to carbapenems group like Meropenem, Doripenem showed intermediate action. In case of gram negative organism; antibiotics Colistin, Amikacin, Tigecycline, Polymyxin-B, Tobramycin showed sensitivity; Ampicillin, Amoxicillin, Ciprofloxacin showed resistance and Cefepime, Aztreonam and Ceftriaxone showed intermediate action.

Keywords: Anatomical therapeutic chemical (ATC), antibiotics, defined daily doses (DDD), resistance pattern, sensitivity pattern.
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