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ANTIOXIDANT ACTIVITY OF GREWIA UMBELLIFEREA – IN VITRO AND IN VIVO STUDY. G Gomathy, T Vijay, K Sarumathy, S Gunasekaran, S Palani

ANTIOXIDANT ACTIVITY OF GREWIA UMBELLIFEREA – IN VITRO AND IN VIVO STUDY.

G Gomathy, T Vijay, K Sarumathy, S Gunasekaran, S Palani

International Journal of Pharmacology & Toxicology Science 2013; 3(1): 32-38

Abstract

Antioxidant activity of Grewia umbelliferea bark was studied both by in-vitro and in vivo models. The ethyl acetate, methanol and water extracts exhibited strong antioxidant activity as evidenced by the low IC50 values in both 1, 1-diphenyl-2-picryl hydrazyl (DPPH) and nitric oxide methods. The values were found to be less or comparable to those of ascorbic acid and rutin, the standards used. Administration of the successive methanol and water extracts at 50 and 100 mg/kg body weight given for four days prior to Indomethacin treatment caused a significant increase in the level of superoxide dismutase (SOD) and catalase and a significant decrease in the level of thiobarbituric acid reactive substances (TBARS),when compared to Indomethacin treated control in both intestinal tract. These changes observed at 100 mg/kg body weight treatment were comparable to those observed for standard vitamin E at 50 mg/kg treatment. The results support significant antioxidant nature of Grewia umbelliferea bark extracts.

Keywords: Antioxidant, Grewia Umbelliferea bark, 1, 1-diphenyl-2-picryl hydrazyl (DPPH); nitric oxide, Indomethacin
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