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EVALAUATION OF EFFECT OF DIMETHOATE INTOXICATION ON MALE RAT REPRODUCTIVE PERFORMANCES. El-Medany Azzaa, Guemei Aidab, Bassioni Yieldez, Al-Dahmash Abdullah, EL-Medany Jamila, l-Shaarawi Sanaa

EVALAUATION OF EFFECT OF DIMETHOATE INTOXICATION ON MALE RAT REPRODUCTIVE PERFORMANCES.

El-Medany Azzaa, Guemei Aidab, Bassioni Yieldez, Al-Dahmash Abdullah, EL-Medany Jamila, l-Shaarawi Sanaa

International Journal of Pharmacology & Toxicology Science 2012; 2(3):32-49.

Abstract

Organophosphorus compounds are widely used in industry, agriculture and for public health purposes. The aim of this work was to study the toxicity of dimethoate on fertility in adult male rats and the possible underlying mechanism of action. The treated groups received dimethoate orally via gavage at doses 7, 10.5 & 21mg/kg daily for 90 days. A significant increase (p<0.05) in feed consumption, body weight gain, relative weights of testes, epididymis and intra-testicular cholesterol level, follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin was found in rats treated with dimethoate. A significant decrease (p<0.05) in absolute weight of testes and epididymis, serum cholesterol & testosterone levels, serum acetylcholine esterase (AChE) activity, total sperm count, motility and fertility index was observed in comparison to the control group. Histopathological results also indicated enlargement of interstitial space, inhibition of spermatogenesis and variable degrees of degenerative changes in the seminiferous tubules up to total cellular destruction.

Keywords: Dimethoate, FSH, LH, Prolactin, Testosterone.
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