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COMPARATIVE ANALYSIS OF EFFECT OF PREGABALIN, AMITRIPTYLINE AND LAMOTRIGINE IN STREPTOZOTOCIN INDUCED DIABETIC PERIPHERAL NEUROPATHY IN ALBINO RATS. Rajesh M , Mohapatra S, Swain TR

COMPARATIVE ANALYSIS OF EFFECT OF PREGABALIN, AMITRIPTYLINE AND LAMOTRIGINE IN STREPTOZOTOCIN INDUCED DIABETIC PERIPHERAL NEUROPATHY IN ALBINO RATS.

Rajesh M , Mohapatra S, Swain TR

International Journal of Pharmacology & Toxicology Science 2011; 1: 16-23

Abstract

Aim
Management of diabetic neuropathy (DN) is very challenging. Anti-depressants like amitriptyline and anti-convulsants like carbamazepine, gabapentin, pregabalin and lamotrigine have been used, but with uncertain efficacy. Hence this study aims to evaluate the efficacy of pregabalin, amitriptyline and lamotrigine on streptozotocin (STZ) induced Diabetic peripheral neuropathy (DPN) in albino rats, using two different anti-nociceptive models i.e. measured caudal compression (MCC) test and tail flick latency (TFL) test.
Materials & Methods
For this study 48 albino Rats of either sex were selected and divided into 8 equal groups. Basal blood glucose level (BGL), Squeak threshold and TFL were measured before injecting Streptozotocin 65mg/kg i.p. and repeated after 6 weeks. Rats with BGL above 300mg/dl and showing significant rise in nociceptive threshold at 6 weeks were confirmed to have developed DPN and were included for further study. MCC test and TFL test were performed after oral administration of distilled water, amitriptyline 5, 10, pregabalin 30, 60 and lamotrigine 10, 20 mg/kg. The results were analysed statistically.
Result
Pregabalin (30-60mg/kg) significantly decreased hyperalgesia to a greater extent and for a longer duration than amitriptyline (5-10mg/kg) and lamotrigine (10-20mg/kg).
Conclusion
Pregabalin is more effective than Amitriptyline and Lamotrigine in DPN.


Key words: Diabetic peripheral neuropathy, streptozotocin, anticonvulsants, antidepressants.
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