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THE STUDY OF ANTI-INFLAMMATORY ANTI-PYRETIC AND ANTI-NOCICEPTIVE ACTIVITIES OF EXTRACT FROM LEAVES OF LABISIA PUMILA. Patrick N Okechukwu, Catherine Moyinoluwa Ikujuni

THE STUDY OF ANTI-INFLAMMATORY ANTI-PYRETIC AND ANTI-NOCICEPTIVE ACTIVITIES OF EXTRACT FROM LEAVES OF LABISIA PUMILA.

Patrick N Okechukwu and Catherine Moyinoluwa Ikujuni

International Journal of Pharmacology & Toxicology Science 2012; 2(2): 12-27

Abstract

The methanol leaf extract of Labisia pumila (MELP) and dichloromethane leaf extract of Labisia pumila (DELP) were investigated for its anti-inflammatory, analgesic and antipyretic effects. The phytochemical screening of the extract was also investigated. In the anti-inflammatory test, MELP and DELP (100mg/kg) inhibited significantly the acetic acid induced writhing by 71.1% and 78.34%, respectively, compared to positive control (aspirin 100 mg/kg) value 88.93% (p< 0.05). MELP and DELP (100mg/kg) was able to reduced 50% of paw oedema, induced by carrageenan, compare to positive control (indomethacin 10 mg/kg) value of 42.9% (p< 0.05). In the anti-nociceptive test, the MELP and DELP (100mg/kg) significantly reduced the licking time in both early and late phase of formalin test by 42.77 and 43.23%, 68.41 and 49.17%0, respectively, in the relation to positive control (aspirin 100mg/kg) value 75.17 and 100% (p< 0.01). Similarly, MELP and DELP (100mg/kg) also showed significant effects on hot plate test by increasing the MPE at (45mins) to 6.83±0.79, 7.83±0.79, respectively, compared to (morphine 5 mg/kg) 8.18±0.9 (p< 0.01). Treatment with MELP and DELP (100mg/kg) showed a significant reduction in yeast- induced pyrexia in the fourth hour by 4.5% and 5.4%, respectively, compared to positive control (aspirin 100 mg/kg) value 4.3% (p< 0.01). Phytochemical screening of the extracts indicated the presence of flavonoids, steroids and saponins. The present study confirmed that extracts from the leaves of L.pumila exhibited anti-inflammatory, antinociceptive and anti-pyretic activities and these effects might be due to the constituents’ phytochemicals.

Keywords: Anti-inflammatory, antinociceptive, anti-pyretic, Labisia pumila, dichloromethane, methanol
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